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Keil uVision Run Issue

In my simply blink project I use STM32F103 and Keil C version V5.26.2.0. After building target successful it shows 0 error and warning, and also load code successful too. But the problem is the code doesn't run. (It's not about the code or setting because when I run another kit, it works fine).
When I turn to Debug mode, the Load icon is dimmed and cannot click it. Watch Peripherals -> GPIOC -> ODR13 (LED) doesn't switch logic.
So why this is suddenly happening? Has anyone run into an issue like this?