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Need a Help, Design issue

Hello,

I am Building a Embedded Controller,which has 40+ IO's and need 8 Channel ADC. I have designed it using 89c51/52 and 8255's. But i am trying to build the same in a single chip provided 48 io's. ADC(optional),UART(reqd).
Constraint is that i have a programmer which supports only 48 DIP packages.
Would be helpful if anybody can guide me in selecting a Chip and a programmer(Cost Effective!). Package - Any.
Any guides/reference for how to program this IC
http://www.keil.com/dd/chip/3449.htm