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cerial port to I2C??

I HAVE ANOTHER QUESTION:

I like to interface the serial port of my PC to a I2C bus. does anyone have a schematic and software for that? thanks advanced.

and another question:

I have to design a master I2C that will command around 100 slaves distributed over 200-307m distance, is there any precautions to consider with such a number of slaves and such distances.

ou are thanks